Table 3.
Adjusted associations of CRP, fibrinogen and albumin with longitudinal decline in kidney function, overall and stratified by diabetes and hypertension
| Overall | Adjusted** mean (SD) | Adjusted*** mean (SD) | |||
|---|---|---|---|---|---|
| Biomarker | Adjusted* mean (SD) | No diabetes | Diabetes | No hypertension | Hypertension |
| CRP quartiles | |||||
| <1.24 | −1.88 (2.62) | −1.68 (2.54) | −2.24 (2.83) | −1.63 (2.47) | −2.09 (2.70) |
| 1.24–2.39 | −1.76 (2.58) | −1.80 (2.43) | −2.29 (4.28) | −1.64 (2.42) | −1.84 (2.70) |
| 2.40–4.19 | −1.71 (2.59) | −1.62 (2.46) | −2.23 (3.57) | −1.67 (2.70) | −2.12 (2.59) |
| > 4.19 | −1.94 (2.63) | −1.78 (2.44) | −2.77 (3.56) | −1.45 (2.25) | −1.90 (2.85) |
| P-value for trend | 0.27 | 0.60 | 0.26 | 0.95 | 0.64 |
| Fibrinogen quartiles | |||||
| <275 | −1.93 (2.63) | −1.83 (2.44) | −2.58 (3.53) | −1.46 (2.36) | −1.85 (2.50) |
| 275–311 | −1.68 (2.57) | −1.76 (2.54) | −2.35 (3.37) | −1.52 (2.62) | −2.07 (2.71) |
| 312–361 | −1.84 (2.58) | −1.62 (2.30) | −2.04 (3.59) | −1.74 (2.34) | −2.07 (2.92) |
| >361 | −1.84 (2.60) | −1.67 (2.43) | −2.90 (3.50) | −1.66 (2.46) | −1.98 (2.71) |
| P-value for trend | 0.64 | 0.62 | 0.26 | 0.86 | 0.79 |
| Albumin quartiles | |||||
| >4.20 | −1.52 (2.61) | −1.51 (2.42) | −1.57 (3.42) | −1.31 (2.44) | −1.68 (2.71) |
| 4.01–4.20 | −1.69 (2.59) | −1.69 (2.41) | −1.75 (3.43) | −1.51 (2.45) | −1.81 (2.68) |
| 3.81–4.00 | −1.92 (2.58) | −1.79 (2.42) | −2.77 (3.42) | −1.72 (2.42) | −2.08 (2.68) |
| <3.81 | −2.11 (2.58) | −1.87 (2.42) | −3.56 (3.44) | −1.71 (2.44) | −2.42 (2.71) |
| P-value for trend | <0.001 | 0.01 | <0.001 | 0.02 | <0.001 |
*Adjusted for age, gender, race, hypertension, diabetes, smoking, LDL, HDL, prevalent coronary heart disease and prevalent heart failure.
**Adjusted for age, gender, race, hypertension, smoking, LDL, HDL, prevalent coronary heart disease and prevalent heart failure.
***Adjusted for age, gender, race, diabetes, smoking, LDL, HDL, prevalent coronary heart disease and prevalent heart failure.