Table 4.
Odds ratio of kidney disease (defined as eGFR 15–59 mL/min/1.73 m2) in NHANES III (1988–94) participants aged 20 years or older with versus without anaemia by each GFR-estimating method
| Unadjusted model (n = 6734) |
Multivariable model (n = 6621) |
|||||
|---|---|---|---|---|---|---|
| ORSCR | ORCYSC | ORSCR+CYSC | ORSCR | ORCYSC | ORSCR+CYSC | |
| Overalla | 3.47 (2.77, 4.36) | 3.65 (2.65, 5.03) | 3.93 (3.04, 5.09) | 3.31 (2.44, 4.49) | 3.58 (2.01, 6.38) | 3.45 (2.70, 4.15) |
| Ageb | ||||||
| <60 years | 1.91 (0.98, 3.71) | 8.43 (2.68–26.51) | 4.03 (1.94, 8.38) | 2.61 (1.07, 6.33) | 5.22 (2.23, 12.17) | 2.92 (1.14, 7.52) |
| ≥60 years | 3.12 (2.36, 4.13) | 2.59 (1.87, 3.58) | 3.27 (2.44, 4.38) | 3.82 (2.89, 5.06) | 2.85 (2.08, 3.91) | 3.78 (2.89, 4.95) |
| Ethnicityc | ||||||
| Non-Hispanic white | 4.47 (3.30, 6.07) | 4.96 (3.21, 7.66) | 4.96 (3.54, 6.94) | 3.49 (2.42, 5.04) | 4.60 (2.15, 9.82) | 3.62 (2.58, 5.07) |
| Non-Hispanic black | 2.99 (2.02, 4.42) | 2.86 (1.89, 4.32) | 3.21 (2.15, 4.79) | 2.57 (1.72, 3.82) | 2.20 (1.33, 3.65) | 2.61 (1.60, 4.25) |
| Mexican American | 6.85 (3.69, 12.71) | 4.74 (2.13, 10.56) | 7.29 (4.13, 12.87) | 7.94 (3.68, 17.12) | 3.52 (1.24, 10.02) | 10.41 (4.66, 23.25) |
| Genderd | ||||||
| Male | 10.65 (7.14, 15.88) | 9.18 (6.09, 13.85) | 11.43 (7.97, 16.38) | 3.57 (1.86, 6.84) | 2.22 (1.44, 3.43) | 5.91 (3.86, 9.05) |
| Female | 1.97 (1.43, 2.71) | 2.31 (1.53, 3.49) | 2.28 (1.65, 3.13) | 3.34 (2.24, 4.97) | 5.34 (2.36, 12.06) | 3.16 (2.08, 4.79) |
| C-reactive proteine | ||||||
| <1 mg/dL | 3.54 (2.69, 4.67) | 2.97 (2.28, 3.88) | 3.98 (2.94, 5.37) | 3.76 (2.71, 5.21) | 2.75 (1.98, 3.81) | 3.92 (2.87, 5.35) |
| ≥1 mg/dL | 2.30 (1.04, 5.10) | 5.47 (2.24, 13.35) | 2.57 (1.16, 5.68) | 2.01 (0.85, 4.74) | 7.36 (1.98, 27.36) | 2.16 (0.95, 4.94) |
Data presented as OR (95% CI).
SCR, serum creatinine; CYSC, serum cystatin C; SCR + CYSC, serum creatinine and cystatin C.
Multivariable model adjusted for age, ethnicity, gender, diabetes mellitus, hypertension, hypercholesterolaemia, smoking status, BMI, serum albumin, log-CRP and log-TSH.
Multivariable model adjusted for all variables included in overall adjusted model except for age.
Multivariable model adjusted for all variables included in overall adjusted model except for ethnicity.
Multivariable model adjusted for all variables included in overall adjusted model except for gender.
Multivariable model adjusted for all variables in overall adjusted model except for C-reactive protein.