Table 3.

Plasma concentration-time relationship of naltrexone after a single intravenous bolus injection of 2.22 mg/kg of naltrexone hydrochloride (average ± SD; n = 6) in the Wistar, LAD-1 and HAD-1 rats

Time, min	Plasma naltrexone, ng/ml
	Wistar	LAD-1	HAD-1
2	2,262±312	2,291±414	3,743±1,081
5	616±145	653±306	1,040±308
10	312±125	407±199	561±152
20	193±57	258±103	302±41
40	100±39	169±87	189±56
60	63±22	112±49	143±38
90	33±11	77±0	80±28
120	23±10	47±20	53±28
240	6±2	15±10	21±16