. Author manuscript; available in PMC: 2010 Jul 27.

Published in final edited form as: Neuropsychobiology. 2008 Oct 3;58(2):81–90. doi: 10.1159/000159776

Table 4.

Comparison of pharmacokinetic parameters following intravenous bolus administration of naltrexone in Wistar, LAD-1 and HAD-1 rats by analysis of variance

a Comparison of pharmacokinetic parameters

Parameters	LAD-1 rat	HAD-1 rat	Wistar rat	ANOVA result, p
C₀, ng/ml	5,828±2,105.5	9,303±2,105.5	5,632±1,935.2	0.320^a
Half-life, min	63.5±23.4	70.9±33.7	58.9±11	0.724^a
AUC, min × ng/ml	35,547±9,290.6	49,368±14,085.1	26,099±4,493.5	0.013^b
AUC_D, min × kg × ng/ml/mg	16,157.8±4,223	22,440.1±6,402.3	11,863.2±2,042.5	0.013^b
Cl, ml/min/kg	65±14.8	48±14.1	86±13.9	0.007^b
V_ss, ml/kg	3,043.5±871.9	2,439.6±1,271.2	2,651.8±644.2	0.594^a
AUMC, min × min × ng/ml	1,829,172.426± 1,000,206.778	1,536,266.505± 607,546.849	656,693.955± 216,576.746	0.079^c
MRT, min	49±16.5	51.8±26.8	31.1±6.6	0.098^c

C₀ = Extrapolated concentration at zero time; AUC = area under the blood level-time curve; AUC_D = dose-normalized AUC; Cl = clearance; V_ss = volume of distribution at steady state; AUMC = area under the first moment curve; MRT = mean residence time.

Not significant;

highly significant;

not significant – borderline.