b A typical analysis of variance table for the pharmacokinetic parameters (randomized complete block experimental design involving 3 types of rats with 6 replications)
| Factor | Type | Levels | Values |
|---|---|---|---|
| Replications | fixed | 6 | I, II, III, IV, V, VI |
| Rats | fixed | 3 | WISTAR, HAD-1, LAD-1 |
| Analysis of variance for clearance (response variable: clearance) | ||||||
|---|---|---|---|---|---|---|
| Source | DF | SS | MS | FC | P | FT |
| Replications | 5 | 480.9 | 96.2 | 0.37 | 0.858 (not significant) | 3.33 (0.05, 5, 10) |
| Rat | 2 | 4,469.5 | 2,234.7 | 8.59 | 0.007 (significant) | 4.10 (0.05, 2, 10) |
| Error | 10 | 2,600.3 | 260.0 | |||
| Total | 17 | 7,550.8 | ||||
| Tukey simultaneous tests (response variable: clearance): all pairwise comparisons among types of rat | ||||
|---|---|---|---|---|
| Difference of means |
SE of difference |
Adjusted T value |
p value | |
| Rat (Wistar subtracted from) | ||||
| HAD-1 | −38.60 | 9.310 | −4.146 | 0.0051 (significant) |
| LAD-1 | −18.86 | 9.310 | −2.026 | 0.1563 (not significant) |
| Rat (HAD-1 subtracted from) | ||||
| LAD-1 | 19.73 | 9.310 | 2.119 | 0.1354 (not significant) |