Parameter | Pairwise comparison of means | p value |
---|---|---|
AUC, min × ng/ml | HAD-1 vs. LAD-1 | 0.1204 (not significant) |
HAD-1 vs. Wistar | 0.0105 (highly significant) | |
LAD-1 vs. Wistar | 0.3315 (not significant) | |
| ||
AUC_D, min × kg × ng/ml/mg | HAD-1 vs. LAD-1 | 0.1204 (not significant) |
HAD-1 vs. Wistar | 0.0105 (highly significant) | |
LAD-1 vs. Wistar | 0.3315 (not significant) | |
| ||
Cl, ml/min/kg | HAD-1 vs. LAD-1 | 0.2174 (not significant) |
HAD-1 vs. Wistar | 0.0051 (highly significant) | |
LAD-1 vs. Wistar | 0.1079 (not significant) |
When a significant difference was found, Tukey simultaneous tests were employed. AUC = Area under the blood level-time curve; AUC_D= dose-normalized AUC; Cl = clearance.