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Twist binding sites are required for Notch activation of argosNRE. (A) Response of the indicated enhancers to NICD in transient transfection assays in DmD8 cells, expressed as fold change (dark-grey bars) relative to expression levels in the absence of Notch (light-grey bars). Mutating Twi binding sites as indicated abolishes aosNRE responsiveness. (B,C) In vivo, mutations of the same sites lead to a decrease in expression (C) compared with the control enhancer (B).
