Figure 6.

Effect of deletion of ebpABC_fm in a murine model of UTI, using a mixed inoculum. (A) Percentage of bacteria recovered from kidneys. (B) Percentage of bacteria recovered from bladders. Two independent experiments are shown in both panels. Exp. 1, mice infected with equal CFUs of TX82 and TX82ΔebpABC_fm (2.8 × 10⁶ CFU/mouse); Exp. 2, mice infected with 10-fold overdose of TX82ΔebpABC_fm (2.2 × 10⁷ CFU/mouse) versus TX82 (2.2 × 10⁶ CFU/mouse). Horizontal bars represent the means of percentages of total bacteria in kidneys and bladders Statistical analyses were performed by the paired t test and p values are shown in the figure. Empty circles and empty triangles represent percentages of TX82 and TX82ΔebpABC_fm in inocula, respectively, while solid circles and solid triangles represent percentages of TX82 and TX82ΔebpABC_fm recovered from kidneys and bladders 48 h post infection, respectively.