Skip to main content
NCBI home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1962 Jun;41(6):1312–1333. doi: 10.1172/JCI104594

STUDIES OF I131-ALBUMIN CATABOLISM AND DISTRIBUTION IN NORMAL YOUNG MALE ADULTS*

Warren L Beeken 1,2,†, Wade Volwiler 1,2, Patrick D Goldsworthy 1,2, Lars E Garby 1,2,‡, William E Reynolds 1,2,§, Rose Stogsdill 1,2, Richard S Stemler 1,2,ǁ
PMCID: PMC291046  PMID: 13866511

Full text

PDF
1312

Images in this article

1313Image
on p.1313

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ARMSTRONG F. B., MARGEN S., TARVER H. Plasma protein. VII. Site of degradation of serum albumin. Proc Soc Exp Biol Med. 1960 Mar;103:592–596. doi: 10.3181/00379727-103-25606. [DOI] [PubMed] [Google Scholar]
  2. BAUMAN A., ROTHSCHILD M. A., YALOW R. S., BERSON S. A. Distribution and metabolism of I131 labeled human serum albumin in congestive heart failure with and without proteinuria. J Clin Invest. 1955 Sep;34(9):1359–1368. doi: 10.1172/JCI103184. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BENNHOLD H., KALLEE E. Comparative studies on the half-life of I 131-labeled albumins and nonradioactive human serum albumin in a case of analbuminemia. J Clin Invest. 1959 May;38(5):863–872. doi: 10.1172/JCI103868. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. BENSON J. A., Jr, KIM K. S., BOLLMAN J. L. Extravascular diffusion of protein. Am J Physiol. 1955 Jul;182(1):217–220. doi: 10.1152/ajplegacy.1955.182.1.217. [DOI] [PubMed] [Google Scholar]
  5. BERSON S. A., YALOW R. S. Chemical and biological alterations induced by irradiation of I 131 labeled human serum albumin. J Clin Invest. 1957 Jan;36(1 Pt 1):44–50. doi: 10.1172/JCI103408. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. BERSON S. A., YALOW R. S., SCHREIBER S. S., POST J. Tracer experiments with I131 labeled human serum albumin: distribution and degradation studies. J Clin Invest. 1953 Aug;32(8):746–768. doi: 10.1172/JCI102789. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. BERSON S. A., YALOW R. S. The distribution of I131 labeled human serum albumin introduced into ascitic fluid: analysis of the kinetics of a three compartment catenary transfer system in man and speculations on possible sites of degradation. J Clin Invest. 1954 Mar;33(3):377–387. doi: 10.1172/JCI102910. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. BLAHD W. H., FIELDS M., GOLDMAN R. The turnover rate of serum albumin in the nephrotic syndrome as determined by I 131-labeled albumin. J Lab Clin Med. 1955 Nov;46(5):747–756. [PubMed] [Google Scholar]
  9. BLOOM H. J., CROCKETT D. J., EKINS R. P., LEDLIE E. M., TAYLOR D. M., VASSAR P. S. The stability of radioactive iodinated serum albumin preparations in man. Br J Radiol. 1956 Nov;29(347):585–587. doi: 10.1259/0007-1285-29-347-585. [DOI] [PubMed] [Google Scholar]
  10. BLOOM H. J., CROCKETT D. J., STEWART F. S. The effects of radiation on the stability of radio-iodinated human serum albumin. Br J Radiol. 1958 Jul;31(367):377–383. doi: 10.1259/0007-1285-31-367-377. [DOI] [PubMed] [Google Scholar]
  11. BRADY L. W., COOPER D. Y., COLODZIN M., MCCLENATHAN J. E., KING E. R., WILLIAMS R. Blood volume studies in normal humans. Surg Gynecol Obstet. 1953 Jul;97(1):25–32. [PubMed] [Google Scholar]
  12. CAMPBELL R. M., CUTHBERTSON D. P., MATTHEWS C. M., MCFARLANE A. S. Behaviour of 14C- and 131I-labelled plasma proteins in the rat. Int J Appl Radiat Isot. 1956 Jul;1(1-2):66–84. doi: 10.1016/0020-708x(56)90020-5. [DOI] [PubMed] [Google Scholar]
  13. COHEN S. Chromatographic behaviour of human albumin labelled with iodine-131. Nature. 1959 Feb 7;183(4658):393–394. doi: 10.1038/183393b0. [DOI] [PubMed] [Google Scholar]
  14. COHEN S., FREEMAN T., McFARLANE A. S. Metabolism of I-131-labelled human albumin. Clin Sci. 1961 Apr;20:161–170. [PubMed] [Google Scholar]
  15. COHEN S., GORDON A. H. Catabolism of plasma albumin by the perfused rat liver. Biochem J. 1958 Dec;70(4):544–551. doi: 10.1042/bj0700544. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. COHEN S., SCHAMROTH L. Metabolism of 131 I-labelled albumin in African subjects. Br Med J. 1958 Jun 14;1(5084):1391–1394. doi: 10.1136/bmj.1.5084.1391. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. DOUPE J., FERGUSON M. H., HILDES J. A. Seasonal fluctuations in blood volume. Can J Biochem Physiol. 1957 Mar;35(3):203–213. [PubMed] [Google Scholar]
  18. FRANKS J. J., REEVE E. B. Errors in volume measurement from absorption losses of albumin-I131. Proc Soc Exp Biol Med. 1956 Nov;93(2):299–302. doi: 10.3181/00379727-93-22737. [DOI] [PubMed] [Google Scholar]
  19. FREEMAN T. The biological behaviour of normal and denatured human plasma albumin. Clin Chim Acta. 1959 Nov;4:788–792. doi: 10.1016/0009-8981(59)90029-4. [DOI] [PubMed] [Google Scholar]
  20. FRIEDMAN J. J. Vascular-extravascular equilibration of radioactive iodinated albumin in mice. Am J Physiol. 1957 Oct;191(1):115–118. doi: 10.1152/ajplegacy.1957.191.1.115. [DOI] [PubMed] [Google Scholar]
  21. GARROW J. S., WATERLOW J. C. Observations on Evans blue dye as a tracer for human plasma albumin. Clin Sci. 1959 Feb;18(1):35–43. [PubMed] [Google Scholar]
  22. GITIL D., LANDING B. H., WHIPPLE A. The localization of homolgous plasma proteins in the tissues of young human beings as demonstrated with fluorescent antibodies. J Exp Med. 1953 Feb 1;97(2):163–176. doi: 10.1084/jem.97.2.163. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. GITLIN D., JANEWAY C. A., FARR L. E. Studies on the metabolism of plasma proteins in the nephrotic syndrome. I. Albumin, gamma-globulin and iron-binding globulin. J Clin Invest. 1956 Jan;35(1):44–56. doi: 10.1172/JCI103251. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. GITLIN D., KLINENBERG J. R., HUGHES W. L. Site of catabolism of serum albumin. Nature. 1958 Apr 12;181(4615):1064–1065. doi: 10.1038/1811064b0. [DOI] [PubMed] [Google Scholar]
  25. GOLDSWORTHY P. D., VOLWILER W. Comparative metabolic fate of chemically (I 131) and biosynthetically (C14-or S35-) labeled proteins. Ann N Y Acad Sci. 1957 Aug 30;70(1):26–48. doi: 10.1111/j.1749-6632.1957.tb35375.x. [DOI] [PubMed] [Google Scholar]
  26. GORDON R. S., Jr Exudative enteropathy: abnormal permeability of the gastrointestinal tract demonstrable with labelled polyvinylpyrrolidone. Lancet. 1959 Feb 14;1(7068):325–326. doi: 10.1016/s0140-6736(59)90309-5. [DOI] [PubMed] [Google Scholar]
  27. GREEN M., MILLER L. L. Protein catabolism and protein synthesis in perfused livers of normal and alloxan-diabetic rats. J Biol Chem. 1960 Nov;235:3202–3208. [PubMed] [Google Scholar]
  28. HLAD C. J., Jr, TANZ R. An analysis of technical errors in radioalbumin blood volume methods and presentation of a modified method. J Lab Clin Med. 1958 Aug;52(2):289–298. [PubMed] [Google Scholar]
  29. HOLMAN H., NICKEL W. F., Jr, SLEISENGER M. H. Hypoproteinemia antedating intestinal lesions, and possibly due to excessive serum protein loss into the intestine. Am J Med. 1959 Dec;27:963–975. doi: 10.1016/0002-9343(59)90180-9. [DOI] [PubMed] [Google Scholar]
  30. HOROWITZ M. I., HOLLANDER F. Serum proteins in anacid gastric mucinous secretions. J Biol Chem. 1961 Mar;236:770–773. [PubMed] [Google Scholar]
  31. INKLEY S. R., BROOKS L., KRIEGER H. A study of methods for the prediction of plasma volume. J Lab Clin Med. 1955 Jun;45(6):841–850. [PubMed] [Google Scholar]
  32. KATZ J., ROSENFELD S., SELLERS A. L. Role of the kidney in plasma albumin catabolism. Am J Physiol. 1960 Apr;198:814–818. doi: 10.1152/ajplegacy.1960.198.4.814. [DOI] [PubMed] [Google Scholar]
  33. KATZ J., ROSENFELD S., SELLERS A. L. Sites of plasma albumin catabolism in the rat. Am J Physiol. 1961 Jun;200:1301–1306. doi: 10.1152/ajplegacy.1961.200.6.1301. [DOI] [PubMed] [Google Scholar]
  34. LEWALLEN C. G., BERMAN M., RALL J. E. Studies of iodoalbumin metabolism. I. A mathematical approach to the kinetics. J Clin Invest. 1959 Jan 1;38(1 Pt 1):66–87. doi: 10.1172/JCI103796. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. LEWALLEN C. G., RALL J. E., BERMAN M. Studies of iodoalbumin metabolism. II. The effects of thyroid hormone. J Clin Invest. 1959 Jan 1;38(1 Pt 1):88–101. doi: 10.1172/JCI103798. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. MARGEN S., TARVER H. Comparative studies on the turnover of serum albumin in normal human subjects. J Clin Invest. 1956 Oct;35(10):1161–1172. doi: 10.1172/JCI103370. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. MATTHEWS C. M. The theory of tracer experiments with 131I-labelled plasma proteins. Phys Med Biol. 1957 Jul;2(1):36–53. doi: 10.1088/0031-9155/2/1/305. [DOI] [PubMed] [Google Scholar]
  38. MCFARLANE A. S. Labelling of plasma proteins with radioactive iodine. Biochem J. 1956 Jan;62(1):135–143. doi: 10.1042/bj0620135. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. MILLER L. L., BLY C. G., WATSON M. L., BALE W. F. The dominant role of the liver in plasma protein synthesis; a direct study of the isolated perfused rat liver with the aid of lysine-epsilon-C14. J Exp Med. 1951 Nov;94(5):431–453. doi: 10.1084/jem.94.5.431. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. McFARLANE A. S. Use of labelled plasma proteins in the study of nutritional problems. Prog Biophys Biophys Chem. 1957;7:115–163. [PubMed] [Google Scholar]
  41. PENN N. W. The requirements for serum albumin metabolism in subcellular fractions of liver and brain. Biochim Biophys Acta. 1960 Jan 1;37:55–63. doi: 10.1016/0006-3002(60)90078-0. [DOI] [PubMed] [Google Scholar]
  42. ROTHSCHILD M. A., BAUMAN A., YALOW R. S., BERSON S. A. Tissue distribution of I131 labeled human serum albumin following intravenous administration. J Clin Invest. 1955 Sep;34(9):1354–1358. doi: 10.1172/JCI103183. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. SCHULTZ A. L., HAMMARSTEN J. F., HELLER B. I., EBERT R. V. A critical comparison of the T-1824 dye and iodinated albumin methods for plasma volume measurement. J Clin Invest. 1953 Feb;32(2):107–112. doi: 10.1172/JCI102717. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. SCHWARTZ M., JARNUM S. Gastrointestinal protein loss in idiopathic (hypercatabolic) hypoproteinaemia. Lancet. 1959 Feb 14;1(7068):327–330. doi: 10.1016/s0140-6736(59)90310-1. [DOI] [PubMed] [Google Scholar]
  45. SENN L. Y., KARLSON K. E. Methodologic and actual error of plasma volume determination. Surgery. 1958 Dec;44(6):1095–1105. [PubMed] [Google Scholar]
  46. SKINNER S. M., CLARK R. E., BAKER N., SHIPLEY R. A. Complete solution of the three-compartment model in steady state after single injection of radioactive tracer. Am J Physiol. 1959 Feb;196(2):238–244. doi: 10.1152/ajplegacy.1959.196.2.238. [DOI] [PubMed] [Google Scholar]
  47. STEINFELD J. L. Difference in daily albumin synthesis between normal men and women as measured with II31-labeled albumin. J Lab Clin Med. 1960 Jun;55:904–911. [PubMed] [Google Scholar]
  48. STEINFELD J. L., GREENE F. E., TABERN D. L., PATON R. R., FLICK A. L. Degradation of iodinated human serum albumin prepared by various procedures. J Lab Clin Med. 1958 May;51(5):756–766. [PubMed] [Google Scholar]
  49. STERLING K. The turnover rate of serum albumin in man as measured by I131-tagged albumin. J Clin Invest. 1951 Nov;30(11):1228–1237. doi: 10.1172/JCI102542. [DOI] [PMC free article] [PubMed] [Google Scholar]
  50. STRUMIA M. M., COLWELL L. S., DUGAN A. The measure of erythropoiesis in anemias. I. The mixing time and the immediate post-transfusion dissappearance of T-1824 dye and of Cr-51-tagged erythrocytes in relation to blood volume determination. Blood. 1958 Feb;13(2):128–145. [PubMed] [Google Scholar]
  51. Sterling K. THE EFFECT OF CUSHING'S SYNDROME UPON SERUM ALBUMIN METABOLISM. J Clin Invest. 1960 Dec;39(12):1900–1908. doi: 10.1172/JCI104214. [DOI] [PMC free article] [PubMed] [Google Scholar]
  52. Suchinsky R. T. A STUDY OF EIGHT HEATED PLASMA PROTEIN PREPARATIONS. J Clin Invest. 1960 Dec;39(12):1953–1962. doi: 10.1172/JCI104220. [DOI] [PMC free article] [PubMed] [Google Scholar]
  53. VOLWILER W., GOLDSWORTHY P. D., MACMARTIN M. P., WOOD P. A., MACKAY I. R., FREMONT-SMITH K. Biosynthetic determination with radioactive sulfur of turn-over rates of various plasma proteins in normal and cirrhotic man. J Clin Invest. 1955 Jul;34(7 Pt 1):1126–1146. doi: 10.1172/JCI103162. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. VOTAW D. F., Jr, KIMBALL A. W., RAFFERTY J. A. Compound symmetry tests in the multivariate analysis of medical experiments. Biometrics. 1950 Sep;6(3):259–281. [PubMed] [Google Scholar]
  55. WETTERFORS J., GULLBERG R., LILJEDAHL S. O., PLANTIN L. O., BIRKE G., OLHAGEN B. Role of the stomach and small intestine in albumin breakdown. Acta Med Scand. 1960 Nov 25;168:347–363. doi: 10.1111/j.0954-6820.1960.tb13456.x. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES