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The inflammatory infiltrate in Darier's disease is mostly constituted by CD4+ T lymphocytes (a), with less numerous CD8+ T (b), and a few CD20+ B (c) lymphocytes. Redstained, FOXP3+ nuclei of Tregs are shown in (d) Immunohistochemistry; original magnification, ×200; Scale bar = 75 μm; Chromogen: fuchsin.
