Figure 2.

Role of PPAR-α in the anti-inflammatory property of VB on clinical expression of DNBS-induced colitis and macroscopic damage score. Colon tissues from sham-treated mice (a), colon tissues from DNBS-treated PPAR-αWT (b) or DNBS-treated PPAR-αKO mice (c) from mice at 4 days post DNBS administration, and the colon tissues collected from DNBS-treated mice which have received VB treatment (d). The treatment of PPAR-αWT with VB resulted in a significant decrease in the extent and severity of the macroscopic signs (d). The genetic absence of the PPAR-α receptor significantly reduced the effect of the VB treatment (e). The macroscopic damage score was made by two independent observers (f). Data are means ± SEM of 10 mice for each group. *P < .01 versus Sham; °P < .05 versus DNBS-WT group.