Table 1.
Expression of Claudins in Cancer.
| Type of Malignancy | Claudin gene | Expression | |
|---|---|---|---|
| Breast Carcinoma | CLDN1 | Down | |
| CLDN3 | Up | ||
| CLDN4 | Up | ||
| CLDN7 | Down | ||
| Biliary tract Carcinoma | CLDN4 | Up | |
| Colorectal Carcinoma | CLDN1 | Up | |
| CLDN8 | Down | ||
| CLDN12 | Up | ||
| Endometrial endometrioid Carcinoma | CLDN1 | Down | |
| CLDN2 | Up | ||
| Endometrial seropapillary Carcinoma | CLDN1 | Up | |
| CLDN2 | Down | ||
| Gastric adenocarcinoma | CLDN1 | Up | |
| CLDN3 | Up | ||
| CLDN4 | Up | ||
| CLDN5 | Up | ||
| Hepatocellular carcinoma | CLDN4 | Down | |
| CLDN7 | Up | ||
| Hepatoblastoma (Fetal) | CLDN1 | Up | |
| CLDN2 | Up | ||
| CLDN3 | Down | ||
| CLDN4 | Down | ||
| CLDN7 | Down | ||
| Head & Neck (SCC) | CLDN7 | Down | |
| Lung cancer (Adenocarcinoma) | CLDN1 | Down | |
| CLDN5 | Up | ||
| Lung cancer (SCC) | CLDN1 | Up | |
| CLDN5 | Down | ||
| Meningioma | CLDN1 | Up | |
| Mesothelioma | CLDN4 | Down | |
| CLDN5 | Down | ||
| Metastatic Melanoma | CLDN1 | Down | |
| Oncocytoma | CLDN7 | Down | |
| CLDN8 | Up | ||
| Ovarian epithelial Carcinoma | CLDN1 | Up | |
| CLDN3 | Up | ||
| CLDN4 | Up | ||
| CLDN5 | Up | ||
| CLDN7 | Up | ||
| Ovarian sex cord stromal Tumors | CLDN1 | Down | |
| CLDN3 | Down | ||
| CLDN4 | Down | ||
| CLDN5 | Down | ||
| Pancreatic Carcinoma | CLDN1 | Up | |
| CLDN4 | Up | ||
| Pleura (metastatic adenocarcinoma) | CLDN3 | UP | |
| CLDN4 | UP | ||
| Prostate Carcinoma | CLDN1 | Up | |
| CLDN2 | Down | ||
| CLDN3 | Up | ||
| CLDN4 | Up | ||
| CLDN5 | Down | ||
| CLDN7 | Up | ||
| Renal cell Carcinoma | CLDN1 | Up | |
| CLDN3 | Up | ||
| CLDN4 | Up | ||
| Renal cell Carcinoma (Chromobhobe) | CLDN7 | Up | |
| Tongue (SCC) | CLDN1 | Up | |
| CLDN4 | Up | ||
| CLDN7 | Up | ||
| Thyroid Carcinomas | CLDN1 | Up | |
| CLDN4 | Up | ||
| CLDN7 | Up | ||
| Undifferentiated Thyroid Carcinoma | CLDN1 | Down |