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. Author manuscript; available in PMC: 2010 Jul 27.
Published in final edited form as: J Cereb Blood Flow Metab. 2007 Dec 5;28(4):852–865. doi: 10.1038/sj.jcbfm.9600584

Table 2.

Bias, given as percent of true value, and standard deviation in units of percent of true value (n = 1,024)

DVR = 8 DVR = 8a DVR = 5 DVR = 4 DVR = 3 DVR = 2 DVR = 1
OLS 77.7 (13.8) 87.1 (12.5) 90.1 (11.5) 92 (10.8) 94.9 (9.0) 97.2 (7.3)
TLS 93.5 (23.5) 95.6 (17.5) 94.8 (13.9) 95.4 (12.1) 96.2 (9.6) 97.4 (7.4)
GLLS 95.4 (26.2) 99.8 (20.0) 99.7 (15.3) 100.7 (13.5) 100.0 (10.3) 98.4 (8.1)
LEGA 100.0 (19.7) 105.5 (22.6) 102.5 (16.9) 102.2 (13.9) 102.2 (11.2) 101.4 (8.5)
MA1 107.4 (34.6) 106.9 (24.9) 103.4 (17.1) 102.9 (14.0) 102.9 (11.2) 103.1 (8.8)
PCA1 87.7 (7.3) 91.1 (9.7) 100.1 (8.1) 101.0 (8.1) 101.3 (8.9) 102.0 (8.3) 97.2 (7.2)
PCA2 98.0 (19.0) 99.2 (16.9) 102.6 (16.3) 102.6 (14.9) 102.8 (12.2) 101.9 (10.2) 98.1 (7.6)

Abbreviations: DVR, distribution volume ratio; GLLS, generalized linear least squares; LEGA, likelihood estimation graphical analysis; MA1, multilinear analysis-1; OLS, ordinary least squares; PCA, principal component analysis; TLS, total least squares.

A value of 100 represents ‘no bias’.

a

PCA training set including curve shapes similar to the atypical curve (1% of total curves).