Table 4.
Mean (± SD) clinical and immunological parameters for the not in cluster group (NIC) and 5 microbiological clusters defined in the aggressive periodontitis group.
| NIC | Cluster 1 | Cluster 2 | Cluster 3 | Cluster 4 | Cluster 5 | |
|---|---|---|---|---|---|---|
| n subjects (sites): | 4 (5) | 7 (17) | 26 (106) | 24 (77) | 4 (8) | 2 (8) |
| Variable: | Mean ± SD | Mean ± SD | Mean SD | Mean SD | Mean SD | Mean SD |
| PD (mm) | 4.6 ± 1.1 | 3.6 ± 0.1 | 4.6 ± 1.5 | 4.2 ± 1.1 | 4.4 ± 1.8 | 8.9 ± 1.8 |
| CAL (mm) | 4.6 ± 1.1 | 3.5 ± 1.1 | 4.9 ± 1.6 | 4.4 ± 1.2 | 4.4 ± 1.8 | 9.2 ± 2.6 |
| BOP (%)** | 10 ± 0 | 30 ± 40 | 80 ± 30 | 60 ± 40 | 40 ± 50 | 80 ± 20 |
| GM-CSF (pg/ml) | 3.3 ± 2.7 | 3.6 ± 2.8 | 5.1 ± 3.6 | 3.7 ± 3.0 | 7.2 ± 2.3 | 2.2 ± 2.3 |
| IL-2 (pg/ml) | 2.1 ± 3.3 | 1.6 ± 2.6 | 2.2 ± 4.2 | 1.2 ± 2.0 | 3.1 ± 5.3 | 0.4 ± 0.2 |
| IFN-γ (pg/ml) | 0.2 ± 0.3 | 0.3 ± 0.4 | 0.7 ± 1.2 | 0.9 ± 2.8 | 0.9 ± 1.3 | 0.3 ± 0.3 |
| IL-10 (pg/ml) | 20.3 ± 15.2 | 22.6 ± 19 | 16.4 ± 15.2 | 18.8 ± 16.1 | 42.8 ± 34.0 | 53.2 ± 4.2 |
| IL-13 (pg/ml) | 4.6 ± 7.9 | 0.9 ± 0.7 | 9.0 ± 20.4 | 10.4 ± 19.5 | 72.0 ± 127.2 | 11.3 ± 15.8 |
| IL-6 (pg/ml) | 0.5 ± 0.5 | 4.3 ± 9.2 | 2.7 ± 5.3 | 4.6 ± 8.8 | 0.8 ± 0.4 | 2.2 ± 1.1 |
| IL-1β (pg/ml) | 14.4 ± 13.3 | 9.6 ± 10.7 | 27.2 ± 17.3 | 17.7 ± 11.6 | 26.2 ± 17.2 | 18.4 ± 3.2 |
| TNF-α (pg/ml) | 0.8 ± 0.3 | 3.9 ± 5.4 | 2.0 ± 2.0 | 2.3 ± 3.0 | 1.9 ± 1.0 | 0.4 ± 0.0 |
| Total cytokines | 46.1 ± 14.0 | 46.8 ± 40.1 | 65.3 ± 35.8 | 59.4 ± 36.5 | 154.8 ± 127.0 | 88.4 ± 17.4 |
| IL-1/IL-10* | 1.6 ± 1.8 | 0.6 ± 0.6 | 4.1 ± 4.7 | 2.1 ± 2.5 | 1.7 ± 1.62 | 0.5 ± 0.1 |
*
p<0.05,
**
p<0.001 using the Kruskal-Wallis test.