Skip to main content
. Author manuscript; available in PMC: 2010 Jul 27.
Published in final edited form as: Neuropharmacology. 2008 Nov 7;56(2):541–555. doi: 10.1016/j.neuropharm.2008.10.012

Figure 8. Effect of acute EtOH application on currents evoked by pressure application of NMDA (500 μM) in layer II and layer III pyramidal neurons.

Figure 8

Recordings were obtained in the whole-cell voltage-clamp mode at −20 mV. (A, B) Representative currents produced by exogenous application of NMDA in layer II pyramidal neurons in the absence and presence of EtOH (70 mM) or MK-801 (10 μM). (C) Timecourse of NMDA currents obtained from layer II pyramidal neurons under control conditions and in the presence of EtOH or MK-801 (application represented by the horizontal line). (D–F) Same as above but for layer III pyramidal neurons. The error bars are smaller than the symbols in some cases. Data were normalized with respect to an average of responses obtained in the first 3 min of recording.