Figure 3.

Intake of 2 x 100 mg modafinil does not affect the rebound of EEG slow wave activity (C3A2 derivation, power within 0.75-4.5 Hz) in NREM sleep (stages 2-4) after sleep deprivation in either Val/Val or Met/Met genotype of COMT. Mean slow wave activity in NREM sleep episodes 1-4 in baseline (mean of 2 nights) and recovery nights was expressed as a percentage of the mean all-night values in baseline (dashed vertical lines). Val/Val genotype: black symbols (dots: mean baseline; open triangles: placebo recovery; filled triangles: modafinil recovery). Met/Met genotype: gray symbols (dots: mean baseline; open triangles: placebo recovery; filled triangles: modafinil recovery). Means ± SEM are plotted.

*P < 0.01 (placebo-recovery vs. mean baseline; paired, 2-tailed t-tests)

+P < 0.03 (modafinil-recovery vs. mean baseline; paired, 2-tailed t-tests)