Fig 1.

Schematic depiction of theoretical modeling framework of acute vocal fold injury and repair within this modeling framework. Initial phonotrauma or surgical injury leads to extracellular matrix (ECM) damage and activates platelets, neutrophils, macrophages, and fibroblasts. Activated cells secrete array of mediators (such as cytokines, growth factors, and proteases), which in turn modulate cell functions [f(x)], including migration, proliferation, and death, as well as secretion of mediators and ECM substances. Specific cell sources and functions of each mediator in current agent-based model (ABM) are described in Table 1. IL — interleukin; TNF — tumor necrosis factor; TGF — transforming growth factor; FGF — fibroblast growth factor; MMP — matrix metalloproteinase.