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. Author manuscript; available in PMC: 2010 Jul 27.
Published in final edited form as: Hypertension. 2009 Jul 13;54(3):625–632. doi: 10.1161/HYPERTENSIONAHA.109.133736

Figure 1.

Figure 1

Acute exposure of HUVECs to Ang II selectively decreases GTPCH I activity and reduces levels of total biopterins, BH4, and GTPCH I. A, Levels of total biopterins and BH4 after a 6-hour exposure to Ang II (0.1 μmol/L). Cells were also analyzed for changes in (B) GTPCH I protein levels and (C) total GTPCH I activity. The blot is representative of 3 independent experiments. Results (n=3) were analyzed with a 1-way ANOVA.