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Inhibition of the 26S proteasome in HUVECs abolishes Ang II–induced reductions in GTPCH I and BH4. Confluent cultures were incubated with Ang II in the presence or absence of the proteasome inhibitor MG132 (0.5 μmol/L). MG132 abolished Ang II–induced reduction in (A) GTPCH I protein levels and (B) total biopterin and BH4 levels. The blots shown are representative of 3 independent experiments. Results (n=3) were analyzed with a 1-way ANOVA.
