Table 2.
Differentially Expressed Genes Identified from ECM and Th1/2/3 Arrays
| Gene Symbol | Accession No.* | Gene Name (Function) | Change Ratio† | Rank Difference | P |
|---|---|---|---|---|---|
| Extra Cellular Matrix and Adhesion Molecules | |||||
| Upregulated | |||||
| COL7A1 | NM_000094 | Collagen, type VII, alpha 1 (Adhesion molecule, basement membrane constituent, ECM structural constituent, ECM protease inhibitor) | 0.94 | +3.36 | 0.0981 |
| COL9A1 | NM_001895 | Collagen, type IX, alpha 1 (Adhesion molecule, ECM structural constituent) | 1.34 | +3.00 | 0.0695 |
| COL19A1 | NM_001858 | Collagen, type XIX, alpha 1 (Cell-cell adhesion, ECM structural constituent) | 0.99 | +3.00 | 0.0695 |
| MMP7 | NM_002423 | Matrix metallopeptidase 7 (ECM protease, epithelial cell inflammatory response to virulent bacteria, activation of α-defensins and other innate factors) | 4.30 | +5.00 | 0.0665 |
| VCAN | NM_004385 | Versican (Basement membrane connective tissue link protein, tumour metastasis) | 1.30 | +4.45 | 0.0404 |
| Downregulated | |||||
| COL12A1 | NM_004370 | Collagen, type XII, alpha 1 (Adhesion molecule, ECM structural constituent) | 0.53 | −3.00 | 0.0695 |
| LAMB1 | NM_002291 | Laminin, beta 1 (Structural basement membrane protein) | 0.79 | −3.00 | 0.0695 |
| Th1/Th2/Th3 | |||||
| Upregulated | |||||
| NFATC4 | NM_004554 | Nuclear factor of activated T cells, cytoplasmic, calcineurin dependent-4 (Th2 and induction of IL4 and IL2) | 1.84 | +4.77 | 0.0783 |
| SOCS1 | NM_003745 | Suppressor of Cytokine signaling 1 (Th1 cytokine induced inhibition of IFNγ signaling) | 1.54 | +5.92 | 0.0262 |
| TLR6 | NM_006068 | Toll-like receptor 6 (innate inflammatory response to bacterial lipoproteins with TLR2) | 1.34 | +4.20 | 0.0763 |
| TMED1 | NM_006858 | Transmembrane emp24 protein transport domain containing 1 (Th2, NK2 and NKT2 surface-expressed marker) | 2.36 | +6.11 | 0.0242 |
| Downregulated | |||||
| NFATC1 | NM_172390 | Nuclear factor of activated T cells, cytoplasmic, calcineurin dependent-1 (Th2 cytokine gene expression) | 0.37 | −3.92 | 0.0399 |
*
http://www.ncbi.nlm.nih.gov/Genbank; provided in the public domain by the National Center for Biotechnology Information, Bethesda, MD.
†
Change ratio of expression derived from raw non-normalized values from the array. Percentage of false positives at P < 0.05 = 15; P < 0.1 = 100.