Table 5.
The Thirty Most Downregulated Genes in RGCs with Elevated IOP
| GenBank* | Gene Name | Change Ratio | GO Biological Process |
|---|---|---|---|
| AI411352 | Gja1: gap junction membrane channel protein alpha 1 | −10.46 | Embryonic development, neuronal migration, cell communication, cell-cell signaling, positive regulation of I-κB kinase/NF-κB cascade, neurite morphogenesis, protein oligomerization, regulation of calcium ion transport |
| D13921 | Acat1: acetyl-coenzyme A acetyltransferase 1 | −10.26 | Metabolic process |
| NM_030991 | Snap25: synaptosomal-associated protein 25 | −9.16 | Exocytosis, neurotransmitter secretion, axonogenesis, regulation of synaptogenesis |
| AI411995 | Ube2d3: Ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) | −9.00 | Ubiquitin-dependent protein catabolic process |
| AI717472 | Tyrp1: tyrosinase-related protein 1 | −8.07 | Melanin metabolic process, pigmentation |
| AA957183 | Cit: Citron | −7.89 | Mitotic sister chromatid segregation, dendrite development, generation of neurons |
| BE105102 | Glrx2: Glutaredoxin 2 (thioltransferase) | −7.74 | Transport, response to organic substance, oxidation reduction |
| AW529483 | Slc4a5: Solute carrier family 4, sodium bicarbonate cotransporter, member 5 | −7.67 | Unknown |
| NM_057205 | Ube1c: ubiquitin-activating enzyme E1C | −6.73 | Mitotic cell cycle, protein modification process, metabolic process, regulation of cell cycle |
| AA851874 | Spg3a: spastic paraplegia 3A homolog (human) | −6.64 | Unknown |
| BG380454 | Basp1: brain abundant, membrane attached signal protein 1 | −6.45 | Unknown |
| BE104618 | Dhrs1: Dehydrogenase/reductase (SDR family) member 1 | −6.34 | Metabolic process |
| BE107450 | Nrep: Neuronal regeneration related protein | −5.95 | Regulation of TGFβ receptor signaling pathway, axon regeneration, regulation of neuronal differentiation |
| BG372673 | Trim32: tripartite motif protein 32 | −5.92 | Unknown |
| AI408819 | H3f3b: H3 histone, family 3B | −5.91 | Nucleosome assembly |
| BE120391 | Gabrg2: gamma-aminobutyric acid A receptor, gamma 2 | −5.79 | Transport, synaptic transmission, post-embryonic development |
| AI169170 | Eif4a2: eukaryotic translation initiation factor 4A2 | −5.68 | Translation |
| NM_013128 | Cpe: carboxypeptidase E | −5.61 | Proteolysis, insulin processing |
| BF284830 | Yipf3: Yip1 domain family, member 3 | −5.53 | Cell differentiation |
| NM_013219 | Cadps: Ca2+-dependent secretion activator | −5.24 | Transport, vesicle fusion, positive regulation of calcium ion-dependent exocytosis |
| AI029445 | Ldb2_predicted: LIM domain binding 2 (predicted) | −5.17 | Multicellular organismal development |
| AI172276 | Ppp1r2: protein phosphatase 1, regulatory (inhibitor) subunit 2 | −5.13 | Metabolic process, nervous system development, regulation of signal transduction, regulation of phosphoprotein phosphatase activity |
| BM388861 | Col9a1: procollagen, type IX, alpha 1 | −5.13 | Chondrocyte differentiation, phosphate transport |
| NM_053562 | Rpe65: retinal pigment epithelium 65 | −5.07 | Eye development, regulation of rhodopsin gene expression, retinal metabolic process |
| NM_057104 | Enpp2: ectonucleotide pyrophosphatase/phosphodiesterase 2 | −5.05 | Chemotaxis, metabolic process, lipid catabolic process |
| NM_013011 | Ywhaz: tyrosin 3-monooxygenase/tyyptophan 5-monooxygenase activation protein, zeta polypeptide | −5.03 | Anti-apoptosis, protein targeting, signal transduction |
| AI145413 | Gabra1: gamma-aminobutyric acid A receptor, alpha 1 | −4.94 | Transport, gamma-aminobutyric acid signaling pathway development |
| NM_031825 | Fbn1: fibrillin 1 | −4.91 | |
| AF439397 | Zwint: ZW10 interactor | −4.90 | Exocytosis, cell cycle, mitosis, cell division |
*
http://www.ncbi.nlm.nih.gov/Genbank; provided in the public domain by the National Center for Biotechnology Information, Bethesda, MD.