Table 8.

Gene Sets Enriched/Depleted in Glaucomatous RGC^*

Gene Set	Enrichment Score†	False-Discovery Rate q‡
Enriched in glaucomatous RGCs
Complement coagulation cascades	0.45	<0.0001
Fas pathway	0.50	<0.0001
Prostaglandin and leukotriene metabolism	0.44	<0.0001
JAK/STAT signaling	0.42	<0.0001
G protein coupled receptor database class A rhodopsin-like	0.35	<0.0001
Prostaglandin synthesis regulation	0.47	<0.0001
Caspase pathway	0.47	<0.0001
Depleted in Glaucomatous RGC
Citrate cycle	0.55	<0.0001
Cholesterol biosynthesis	0.81	<0.0001
G-protein-coupled receptor pathway	0.57	<0.0001

^*A total of 639 canonical pathways gene sets (http://www.broad.mit.edu/gsea/msigdb/genesets.jsp?collection=CP#; provided in the public domain by the Broad Institute, Massachusetts of Technology, Cambridge, MA) were calculated by gene set enrichment analysis.

^†Enrichment score (ES) reflects the degree to which a gene set is overrepresented at the top or bottom of a ranked list of genes.

^‡False-discovery rate is the estimated probability that a gene set with a given normalized ES represents a false-positive finding.