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. 2010 Jul 6;10:73. doi: 10.1186/1471-213X-10-73

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Copyright ©2010 Carew et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Altered GSK3β/β-catenin signalling is evident in Irs2^-/-mouse kidney. (A). Twenty μg of kidney protein lysates from Irs2+/+ and Irs2-/- mice injected with insulin were probed by Western blotting with the indicated antibodies. (B) Twenty μg of kidney protein lysates from female Irs2^+/+(n = 3), Irs2^+/-(n = 3) and Irs2^-/-(n = 6) mice were probed with the indicated antibodies. GAPDH was used as loading control. (C) Band intensities were quantified using Scion Image software. The intensity ratio of β-catenin/GAPDH is shown. p *< 0.05. (D) Twenty μg of kidney protein lysates from Irs2^+/+(n = 3), Irs2^+/-(n = 3) and Irs2^-/-(n = 6) mice were probed with anti-c-myc and anti-cyclin D1 antibodies.