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Phosphorylated and total YAP levels are markedly elevated in Irs2-/- mouse kidney. (A) Twenty μg of kidney protein lysates from Irs2+/+ (n = 3), Irs2+/- (n = 3) and Irs2-/- (n = 6) mice probed by Western blotting as indicated. (B) Six 5-6 wk female Irs2+/+ and Irs2-/- mice were injected with insulin as indicated in Materials and Methods. Twenty μg of kidney protein lysates were probed as in (A). GAPDH was used as a loading control.
