Table 3.
Associations between the serum concentrations of tamoxifen, estrogens, FSH1, and SHBG
Variables | Tamoxifen | 4OHtam | 4OHNDtam | NDtam | NDDtam | TamNox | SHBG |
---|---|---|---|---|---|---|---|
All (n = 90) | r | r | r | r | r | r | r |
E2 | 0.295* | 0.131 | 0.211 | 0.148 | 0.315** | 0.232 | -0.048 |
E1 | 0.297* | 0.133 | 0.152 | 0.226 | 0.330** | 0.292* | -0.002 |
E1S | 0.254 | 0.119 | 0.118 | 0.247 | 0.194 | 0.284* | -0.445** |
FSH | 0.118 | 0.065 | 0.269* | 0.134 | 0.031 | 0.178 | 0.095 |
SHBG | -0.027 | 0.034 | 0.088 | 0.000 | 0.048 | 0.103 | |
Wt/Wt EM CYP2D6 (n = 51) | |||||||
FSH | 0.151 | 0.133 | 0.386* | 0.148 | 0.133 | 0.259 | 0.224 |
1FSH, Follicle Stimulating Hormone; SHBG, sex hormone binding globulin; 4OHtam, 4-hydroxytamoxifen; 4OHNDtam, 4-hydroxy-N-demethyltamoxifen; NDtam, N-demethyltamoxifen; NDDtam, N-dedimethyltamoxifen; tamNox, tamoxifen-N-oxide; r, coefficient; E2, estradiol; E1, estrone; E1S, estrone sulfate; Wt/Wt EM, wild type/wild type extensive metabolizer CYP2D6.
r and p values are derived from two-tailed Spearman correlation rank test. The p-values are given after Bonferroni correction for multiple (n = 5) comparisons within this data set, *p < 0.05, and **p < 0.01.