Figure 4. Aβ perforation causes entry of a small organic molecule in parallel with the increase in membrane conductance.

A, the time dependent increase in cellular fluorescence associated with entry of ethidium bromide in presence of Aβ in the pipette. B, the effect of Aβ was blocked by the Na7 peptide. C, Ethidium bromide was unable to enter into the cell in the absence of Aβ. D–E, effect of Aβ on membrane current transferred and fluorescence in the absence and presence of Na7. * denotes a P<0.05 (n = 7–8 neurons).