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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Stem Cells. 2010 Jul;28(7):1186–1195. doi: 10.1002/stem.437

Figure 4.

Figure 4

Bone marrow cells from Fancd2−/− mice show reduced long-term repopulating potential in vivo. (A): Schematic of the competitive bone marrow transplantation strategy. (B): Donor cell engraftment (total leukocytes) at 4 weeks in peripheral blood of recipients transplanted with wild-type or Fancd2−/− donor bone marrow. (C): Donor cell engraftment (total leukocytes) at 16 weeks in peripheral blood of recipients transplanted with wild-type or Fancd2−/− bone marrow. (D): Donor-derived T-cell engraftment (left panel), B cell engraftment (middle panel), and myeloid cell engraftment (right panel) at 16 weeks in peripheral blood of recipients transplanted with wild-type or Fancd2−/− bone marrow. Data in all the plots are average from 15 recipients (n = 3 donor wild-type or Fancd2−/− mice in each group, n = 5 recipient mice per donor sample). Error bars represent SEM. The p values for the statistical difference between the wild-type and Fancd2−/− mice are highly significant (p < .0005).