Table 2.

List of alkylating agents for which CFL1 mRNA levels are biomarker¹ for drug resistance.

Class2	Drugs	Rs	P-value
A2	Porfiromycin	0.771	0.036
A6	Carmustine (BCNU)	1.000	0.000
A6	Chlorozotocin	0.943	0.002
A6	Clomesone	0.943	0.002
A6	Lomustine (CCNU)	0.771	0.036
A6	Mitozolamide	0.943	0.002
A6	PCNU	0.943	0.002
A6	Semustine (MeCCNU)	0.886	0.009
A7	Asaley	0.771	0.036
A7	Carboplatin	0.829	0.021
A7	Chlorambucil	0.829	0.021
A7	Cisplatin	0.829	0.021
A7	Cyclodisone	0.943	0.002
A7	Hepsulfam	0.771	0.036
A7	Iproplatin	1.000	0.000
A7	Mechlorethamine	0.943	0.002
A7	Melphalan	0.771	0.036
A7	Piperazine mustard	0.943	0.002
A7	Piperazinedione	0.771	0.036
A7	Spiromustine	0.886	0.009
A7	Uracil mustard	0.829	0.021
A7	Yoshi-864	0.771	0.036

¹Meta-analysis data of chemotherapeutic drugs from a panel of 33 alkylating agents (from Fig.4A) tested for positive correlation (resistance) between drug GI₅₀ (µM) and the pattern of CFL1 gene expression in six human NSCLC cell lines (A549, EKVX, HOP-92, NCI-H226, NCI-H23, NCI-H460) obtained from the NCI-60 cell panel.

²Mechanism of action codes: A2= alkylating at N-2 position of guanine; A6= alkylating at O-6 position of guanine; A7= alkylating at N-7 position of guanine.