Table 2.
Fasting metabolic parameters of female Cc2+/+ and Cc2−/− mice
| 2-3 Months |
5-6 Months |
|||
|---|---|---|---|---|
| Cc2+/+ | Cc2−/− | Cc2+/+ | Cc2−/− | |
| Visceral Adiposity (%BWT) | 0.51 ± 0.05 | 0.54 ± 0.06 | 0.49 ± 0.07 | 0.82 ± 0.09 A |
| Body Length (cm) | NA | NA | 99.4 ± 1.28 | 102. ± 0.83 |
| Blood Glucose (mg/dl) | 90.3 ± 3.48 | 99.7 ± 6.39 | 94.2 ± 2.66 | 99.9 ± 3.68 |
| Serum Insulin (pM) | 74. ± 3.0 | 124. ± 10.2 A | 58.7 ± 4.80 | 110. ± 21.0 A |
| Serum C-Peptide (pM) | 132. ± 18.5 | 263. ± 29.5 A | 197. ± 26.0 | 453. ± 95.7 A |
| C/I Molar Ratio | 1.72 ± 0.18 | 1.91 ± 0.16 | 3.31 ± 0.33 | 5.09 ± 1.01 |
| Serum Glucagon (ng/ml) | NA | NA | 0.50 ± 0.12 | 0.57 ± 0.10 |
| Serum Somatostatin (ng/ml) | 0.84 ± 0.01 | 0.85 ± 0.01 | NA | NA |
| Serum Leptin (ng/ml) | 2.88 ± 0.18 | 2.92 ± 0.24 | 2.59 ± 0.14 | 3.19 ± 0.24 A |
| Serum Triglyceride (mg/dl) | 78.3 ± 7.51 | 56.8 ± 6.33 A | 75.5 ± 7.99 | 51.5 ± 5.65 A |
| Serum FFA (mEq/L) | 0.51 ± 0.03 | 0.55 ± 0.06 | 0.76 ± 0.09 | 0.74 ± 0.10 |
A
P<0.05 Cc2−/− versus Cc2+/+ mice (n≥7). Mice were fasted overnight prior to blood drawing and determination of serum metabolic parameters except for leptin and somatostatin where mice were fasted for 6 hours. For glucagon, mice were fasted for 6 hours prior to being injected with insulin for an hour and their blood removed.