Table 5.

Analysis of association between AS3MT polymorphisms and the presence of arsenic skin lesions.

Group	N	Genotype frequency (%)			Allele frequency (%)
A-477G		AA	AG	GG	A	G
As-skin lesion	69	26 (38)	33 (48)	10 (14)	85 (62)	53 (38)
Non-lesion	50	21 (42)	21 (42)	8 (16)	63 (63)	37 (37)
		$X_i^2=0.04$, p=0.83			$X_i^2=0.01$, p=0.90
		OR=1.60a 95%CI (0.6–4.3)
Met287Thr		TT	TC	CC	T	C
As-skin lesion	71	60 (84.5)	10 (14.1)	1 (1.4)	130 (91.5)	12 (8.5)
Non-lesion	51	47 (92)	4 (8)	0	98 (96)	4 (4)
		$X_i^2=3.22$, p=0.055			$X_i^2=1.32$, p=0.25
		ORb=4.28a 95%CI (1–18.5)*
T35587C		TT	TC	CC	T	C
As-skin lesion	71	41 (58)	30 (42)	0	112 (79)	30 (21)
Non-lesion	51	30 (59)	21 (41)	0	81 (79)	21 (21)
		$X_i^2=0.02$, p=0.88			$X_i^2=0.1$, p=0.90
		OR=0.76a 95%CI (0.3–1.9)

The genotype and allele distributions of the AS3MT polymorphisms in individuals exposed to inorganic arsenic are shown for groups with and without skin lesions.

Two-sided $X_i^2$ test.

^aLogistic regression models adjusted by age, gender and TWE.

^bComparison between TT and TC+CC;

^*P=0.05.