Table 3.
Association of high frequency Hsp70-2A/G or G/G and Hsp70-homC/C genotypes with various clinico-pathological features of Kangri cancer patients of Kashmir
| Features | Hsp70-2A/G or G/G |
Hsp70-homC/C |
||
|---|---|---|---|---|
| Genotype (%) | Odd's ratio; χ2P | Genotype (%) | Odd's ratio; χ2P | |
| Age | 0.116(95%CI=0.02-0.48) χ2P <0.05 | $NS | ||
| <50 | 23/30 (76.66) | 17/30 (56.66) | ||
| ≥ 50 | 85/88 (96.59) | 43/88 (48.86) | ||
| Clinical tumor stagea | ΦNA | 3.8(95%CI=1.77-8.14)χ2P<0.05 | ||
| T1 (a,b) | 50/60 (83.33) | 40/60 (66.66) | ||
| T2 (a,b) | 58/58 (100) | 20/58 (34.48) | ||
| Histopathological gradingb | ΦNA | 3.43(95%CI=1.59-7.41)χ2P<0.05 | ||
| Grade I | 40/50 (80.00) | 34/50 (68.00) | ||
| Grade II | 68/68 (100) | 26/68 (38.23) | ||
| Lymph node statusc | 7.35(95%CI=1.77-30.52)χ2P<0.05 | 0.06(95%CI=0.02-0.21)χ2P<0.05 | ||
| N1 | 82/85 (96.47) | 31/85 (35.63) | ||
| N0 | 26/33 (78.78) | 29/33 (88.88) | ||
Hsp= Heat shock protein; f = genotype frequencies; χ2 = Chi–square; OR= odds ratio;
NS= Not Significant
NA = Not Applicable; The Chi-square test was used whether significant differences (P-value) in genotype frequencies were observed when patient group was compared with control subjects
Clinical tumor stage: T1 (a,b)= when tumor size ranges from >2 and >5 cm and metastasis to inguinal nodes but no metastasis, T2 (a,b)= tumor of any size, tumor extends to bone, any no of nodes involved and metastasis
Histopathological tumor grade (TNM classification): Determined based on pathological examination.
Lymph node status: N1= involved, N0= not involved