Figure 1.

Nucleotide Sequence Composition Directs the Positioning of H2AZ-Enriched Nucleosomes in Saccharomyces.

The frequency distribution of the combined number of AA, TT, AT, and TA dinucleotides (dashed line) or GG, CC, GC, and CG dinucleotides (solid line) at each base pair along the 147 bp of nucleosomal DNA. Repeats of G+C-rich dinucleotides are more commonly in the major groove (gray shaded areas) facing inward against the nucleosome. A+T-rich dinucleotides are generally in the major grooves facing outward from the nucleosome. The bottom axis shows the distance in base pairs from zero at the center of dyad symmetry. (Adapted by permission from Macmillan Publishers Limited: Nature, Albert et al. [2007], copyright 2007.)