Immunohistologic analysis of junctional adhesion molecule C (JAM-C) in synovial tissue (ST) samples from normal (NL) subjects, patients with osteoarthritis (OA), and patients with rheumatoid arthritis (RA). Frozen sections of normal, OA, and RA ST were stained for JAM-C expression. A and B, Representative photomicrographs of JAM-C (A) and IgG control (B) expression in RA ST (original magnification × 400). C, Mean and SEM JAM-C expression in normal ST, OA ST, and RA ST endothelial cells (ECs). JAM-C was more highly expressed in OA ST (98%) and RA ST (94%) ECs than in normal ST (83%) ECs. D, Mean and SEM JAM-C expression in normal ST, OA ST, and RA ST lining cells. JAM-C was more highly expressed in normal ST (99%) and OA ST (95%) lining cells than in RA ST (85%) lining cells.