FIGURE 2. Effect of curcumin on cortical lesion size.
(A) Cortical lesion at 1, 7, 14, or 21 days following a moderate TBI. Representative brain sections are provided from sham, TBI, or TBI + pre-treatment with 150 mg/kg curcumin mice. A significant lesion is noted on the ipsilateral cortex (right side of images), as compared to the contralateral hemisphere (left side of images). (B) Quantification of lesion area at various time points following injury, as depicted in panel (A). Data are representative of n=4-6 mice/group. No significant differences in lesion size were observed between TBI and TBI + curcumin groups.