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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: J Neurochem. 2010 Jan 20;113(3):637–648. doi: 10.1111/j.1471-4159.2010.06630.x

FIGURE 6. Curcumin reduces IL-1β induced AQP4 expression in cultured astrocytes.

FIGURE 6

Mouse cortical astrocytes were treated with IL-1β (10 ng/mL) in the presence of curcumin (5 μM) or vehicle and AQP4 (A) gene and (B) protein expression were assessed 18h later. (C) The NFκB inhibitors, PDTC (100 μM), or the p65 translocation inhibitor, helenalin (10 μM; HEL) attenuated IL-1β-induced AQP4 gene expression following an 18h treatment. (D) Curcumin reduced IL-1β-induced NFκB (p50 and p65 subunits) binding in cortical astrocytes following a 6h treatment. For all panels, data are expressed as a fold change vs. vehicle and are the mean ± SEM from three independent experiments (n=4/experiment). Data were analyzed using One-Way ANOVA and Student Newman-Keul’s post-hoc test (*p<0.05, **p<0.01, ***p<0.001 vs. vehicle).