TABLE 2.
Association of SNPs with type 2 diabetes in the Delhi and Pune studies and the combined study
| SNP (gene) | Risk/non-risk allele* | Delhi |
Pune |
P (difference in allele frequencies) | Combined |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n Case/control subjects | RAF |
OR (95% CI)† | P | n Case/control subjects | RAF |
OR (95% CI)† | P | n Case/control subjects | RAF |
OR (95% CI)‡ | P | ||||||
| Case subjects | Control subjects | Case subjects | Control subjects | Case subjects | Control subjects | ||||||||||||
| rs1801282 (PPARG) | C/G | 1,019/1,004 | 0.89 | 0.86 | 1.30 (1.08–1.57) | 0.006 | 1,422/1,553 | 0.91 | 0.87 | 1.47 (1.15–1.88) | 1.8 × 10−3 | 0.21 | 2,441/2,557 | 0.90 | 0.87 | 1.37 (1.19–1.59) | 1.6 × 10−5 |
| rs5219 (KCNJ11) | T/C | 1,017/1,006 | 0.39 | 0.35 | 1.17 (1.02–1.33) | 0.02 | 1,417/1,397 | 0.40 | 0.28 | 1.84 (1.55–2.18) | 4.4 × 10−12 | 8.1 × 10−7 | 2,434/2,403 | 0.40 | 0.31 | 1.39 (1.26–1.54) | 6.7 × 10−11 |
| rs7903146 (TCF7L2) | T/C | 1,017/1,006 | 0.40 | 0.29 | 1.67 (1.46–1.92) | 1.7 × 10−13 | 1,423/1,515 | 0.37 | 0.21 | 2.10 (1.77–2.49) | 1.7 × 10−17 | 4.5 × 10−9 | 2,439/2,521 | 0.38 | 0.24 | 1.89 (1.71–2.09) | 4.6 × 10−34 |
| rs13266634 (SLC30A8) | C/T | 1,010/1,000 | 0.79 | 0.75 | 1.32 (1.13–1.53) | 0.0003 | 1,456/1,539 | 0.81 | 0.78 | 1.25 (1.04–1.51) | 0.02 | 0.03 | 2,466/2,539 | 0.80 | 0.77 | 1.34 (1.20–1.50) | 3.4 × 10−7 |
| rs1111875 (HHEX) | G/A | 1,018/1,003 | 0.47 | 0.42 | 1.29 (1.13–1.47) | 0.0001 | 1,454/1,598 | 0.47 | 0.43 | 1.20 (1.03–1.39) | 0.02 | 0.81 | 2,472/2,601 | 0.47 | 0.43 | 1.27 (1.16–1.39) | 5.7 × 10−7 |
| rs10811661 (CDKN2A) | T/C | 1,019/1,006 | 0.89 | 0.87 | 1.3 (1.07–1.59) | 0.009 | 1,431/1,086 | 0.89 | 0.86 | 1.43 (1.09–1.87) | 0.01 | 0.90 | 2,450/2,092 | 0.89 | 0.86 | 1.37 (1.18–1.59) | 5.1 × 10−5 |
| rs4402960 (IGF2BP2) | T/G | 1,019/1,006 | 0.46 | 0.42 | 1.18 (1.03–1.33) | 0.02 | 1,444/868 | 0.50 | 0.46 | 1.30 (1.08–1.56) | 5.5 × 10−3 | 0.03 | 2,463/1,874 | 0.48 | 0.44 | 1.20 (1.09–1.33) | 2.6 × 10−3 |
| rs10946398 (CDKAL1) | C/A | 1,006/990 | 0.24 | 0.21 | 1.19 (1.03–1.38) | 0.02 | 1,456/1,512 | 0.27 | 0.26 | 1.17 (0.98–1.38) | 0.08 | 3.3 × 10−4 | 2,462/2,501 | 0.26 | 0.24 | 1.18 (1.07–1.32) | 1.6 × 10−3 |
*Risk alleles as identified in earlier European studies (9).
†Analysis adjusted for sex, age, and BMI.
‡Analysis adjusted for sex, age, BMI, and geographical region (Delhi and Pune). n, number of subjects genotyped; OR, odds ratio per allele; RAF, risk allele frequency.