TABLE 3.
Comparison of effect sizes of the SNPs in Indians and Europeans
| Gene | SNP | Risk/non-risk allele* | RAF in Indians | RAF in Europeans | Indians† |
Europeans‡ |
||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | |||||
| PPARG | rs1801282 | C/G | 0.87 | 0.86 | 1.37 (1.19–1.59) | 1.6 × 10−5 | 1.14 (1.08–1.20) | 1.7 × 10−6 |
| KCNJ11 | rs5219 | T/C | 0.31 | 0.47 | 1.39 (1.26–1.54) | 6.7 × 10−11 | 1.14 (1.10–1.19) | 6.7 × 10−11 |
| TCF7L2 | rs7903146 | T/C | 0.24 | 0.26 | 1.89 (1.71–2.09) | 4.6 × 10−34 | 1.37 (1.31–1.43) | 1.0 × 10−48 |
| SLC30A8 | rs13266634 | C/T | 0.77 | 0.65 | 1.34 (1.20–1.50) | 3.4 × 10−7 | 1.12 (1.07–1.16) | 5.3 × 10−8 |
| HHEX | rs1111875 | G/A | 0.43 | 0.53 | 1.27 (1.16–1.39) | 5.7 × 10−7 | 1.13 (1.09–1.17) | 5.7 × 10−10 |
| CDKN2A | rs10811661 | T/C | 0.86 | 0.83 | 1.37 (1.18–1.59) | 5.1 × 10−5 | 1.20 (1.14–1.25) | 7.8 × 10−25 |
| IGF2BP2 | rs4402960 | T/G | 0.44 | 0.29 | 1.20 (1.09–1.33) | 2.6 × 10−3 | 1.14 (1.11–1.18) | 8.9 × 10−36 |
| CDKAL1 | rs10946398 | C/A | 0.24 | 0.31 | 1.18 (1.07–1.32) | 1.6 × 10−3 | 1.12 (1.08–1.16) | 4.1 × 10−11 |
*Risk alleles in Europeans, as indicated by DGI study (9).
†ORs and P values obtained for combined analysis of data from the Delhi and Pune studies.
‡ORs and P values obtained from combined analysis of the Diabetes Genetics Initiative (DGI), Finland-United States Investigation of NIDDM Genetics (FUSION), and Wellcome Trust Case Control Consortium (WTCCC) studies (9). OR, odds ratio per allele; RAF, risk allele frequency.