TABLE 4.
Association of SNPs with quantitative traits (glucose and insulin metabolism) in combined control subjects
| Gene SNP | Genotypesmajor hetero minor | n | FPG (mmol/l) |
2-h PPG (mmol/l) |
FPI (pmol/l) |
HOMA-IR |
HOMA-B |
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Median (IQR) | P‡ | Median (IQR) | P‡ | Median (IQR) | P‡ | Median (IQR) | P‡ | Median (IQR) | P‡ | |||
| PPARG | CC | 1,932 | 5.03 (4.61–5.43) | 5.50 (4.56–6.50) | 32.99 (20.00–51.46) | 1.21 (0.71–1.92) | 72.58 (43.10–116.82) | |||||
| rs1801282 | CG | 578 | 5.03 (4.61–5.41) | 5.61 (4.72–6.43) | 30.42 (19.69–47.14) | 1.13 (0.69–1.86) | 67.19 (43.87–117.43) | |||||
| (C/G) | GG | 47 | 4.94 (4.72–5.28) | 0.39 | 5.50 (4.61–6.26) | 0.49 | 27.80 (15.45–44.60) | 0.13 | 1.02 (0.51–1.62) | 0.33 | 65.36 (36.36–105.99) | 6.9 × 10−8* |
| KCNJ11 | CC | 1,143 | 5.00 (4.59–5.39) | 5.50 (4.56–6.50) | 32.00 (19.93–48.82) | 1.18 (0.70–1.87) | 71.68 (42.47–116.18) | |||||
| rs5219 | CT | 1,016 | 5.07 (4.71–5.44) | 5.50 (4.57–6.44) | 32.66 (20.02–51.81) | 1.21 (0.73–1.94) | 68.27 (44.32–112.37) | |||||
| (C/T) | TT | 244 | 5.06 (4.64–5.46) | 0.004* | 5.44 (4.50–6.33) | 0.63 | 32.33 (19.26–55.95) | 0.70 | 1.22 (0.65–1.96) | 0.04* | 73.89 (39.33–122.34) | 0.09 |
| TCF7L2 | CC | 1,449 | 5.00 (4.61–5.44) | 5.33 (4.50–6.28) | 32.26 (19.23–49.64) | 1.18 (0.69–1.87) | 71.83 (42.75–115.76) | |||||
| rs7903146 | CT | 919 | 5.06 (4.61–5.44) | 5.67 (4.70–6.56) | 31.39 (20.04–52.00) | 1.18 (0.71–1.96) | 68.89 (42.29–118.40) | |||||
| (C/T) | TT | 153 | 5.00 (4.66–5.38) | 0.03* | 5.64 (4.78–6.52) | 0.03* | 34.32 (19.32–53.74) | 0.65 | 1.23 (0.72–1.87) | 0.97 | 72.56 (41.30–111.24) | 3 × 10−4* |
| SLC30A8 | CC | 1,487 | 5.03 (4.64–5.44) | 5.44 (4.56–6.44) | 32.50 (19.80–50.00) | 1.19 (0.71–1.89) | 69.79 (43.88–115.71) | |||||
| rs13266634 | CT | 911 | 5.03 (4.61–5.39) | 5.61 (4.78–6.44) | 32.16 (19.86–51.00) | 1.21 (0.69–1.90) | 71.09 (41.60–118.98) | |||||
| (C/T) | TT | 141 | 4.94 (4.50–5.34) | 0.28 | 5.22 (4.34–6.47) | 0.17 | 28.25 (18.17–45.16) | 0.08 | 1.00 (0.63–1.79) | 0.05 | 74.62 (42.25–114.14) | 0.46 |
| HHEX | AA | 847 | 5.03 (4.61–5.39) | 5.44 (4.56–6.44) | 34.00 (20.00–53.86) | 1.26 (0.72–2.02) | 73.85 (45.07–119.81) | |||||
| rs1111875 | AG | 1,274 | 5.00 (4.61–5.44) | 5.44 (4.56–6.51) | 31.39 (20.34–48.18) | 1.16 (0.72–1.81) | 68.49 (43.03–114.09) | |||||
| (A/G) | GG | 480 | 5.06 (4.64–5.46) | 0.17 | 5.67 (4.67–6.39) | 0.20 | 32.93 (18.99–54.00) | 0.04* | 1.25 (0.68–2.02) | 0.02* | 72.74 (41.51–120.19) | 0.48 |
| CDKN2A | TT | 1,554 | 5.06 (4.67–5.44) | 5.39 (4.50–6.39) | 32.64 (19.74–51.12) | 1.21 (0.69–1.94) | 70.52 (42.57–114.69) | |||||
| rs10811661 | TC | 497 | 5.02 (4.57–5.44) | 5.44 (4.56–6.41) | 30.72 (19.14–53.85) | 1.15 (0.68–1.96) | 66.10 (40.97–115.21) | |||||
| (T/C) | CC | 41 | 4.94 (4.73–5.61) | 0.27 | 5.20 (4.35–6.26) | 0.74 | 32.71 (21.74–59.87) | 0.58 | 1.27 (0.77–2.03) | 0.90 | 62.75 (40.79–103.38) | 0.31 |
| IGF2BP2 | GG | 591 | 5.00 (4.65–5.38) | 5.36 (4.56–6.39) | 33.02 (20.28–51.86) | 1.24 (0.73–1.95) | 74.87 (44.54–122.09) | |||||
| rs4402960 | GT | 919 | 5.03 (4.61–5.44) | 5.39 (4.50–6.26) | 30.54 (18.54–50.77) | 1.13 (0.65–1.88) | 65.27 (40.79–111.48) | |||||
| (G/T) | TT | 364 | 5.06 (4.72–5.38) | 0.69 | 5.50 (4.50–6.44) | 0.64 | 31.43 (18.85–49.22) | 0.23 | 1.15 (0.69–1.81) | 0.31 | 67.48 (42.35–109.40) | 0.18 |
| CDKAL1 | AA | 1,466 | 5.05 (4.61–5.44) | 5.52 (4.67–6.50) | 32.16 (19.00–51.81) | 1.17 (0.68–1.93) | 68.88 (40.87–116.96) | |||||
| rs10946398 | AC | 875 | 5.06 (4.68–5.44) | 5.56 (4.50–6.56) | 32.50 (20.44–49.18) | 1.23 (0.74–1.90) | 72.10 (45.05–113.93) | |||||
| (A/C) | CC | 160 | 5.08 (4.61–5.39) | 0.78 | 5.00 (4.39–6.11) | 0.14 | 34.40 (21.60–55.58) | 0.05 | 1.28 (0.79–2.14) | 0.06 | 78.54 (48.10–121.61) | 0.05 |
Data are median (interquartile range).
*Significant P value.
‡Analysis adjusted for sex, age, BMI, and geographical region. IQR, interquartile range.