TABLE 2.
Expected and observed proband DPA1, DPB1, and DPA1-DPB1 frequencies conditioned on HLA DRB1-DQA1-DQB1 linkage disequilibrium in 1,771 type 1 diabetes families
| Proband Fexp (%) | Proband Fobs (%) | Padj | Odds Ratio (Fobs/Fexp) | 95% CI | Proband Fexp (%) | Proband Fobs (%) | Padj | Odds Ratio (Fobs/Fexp) | 95% CI | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| DPA1* | DPA1-DPB1 | ||||||||||
| 0103 | 80.3 | 82.8 | 1.2 | ||||||||
| 0104 | 0.5 | 1.0 | 2.0 | 1.1–3.7 | |||||||
| 0201 | 17.2 | 13.4 | 5E-4 | 0.7 | 0.6–0.9 | ||||||
| 0202 | 2.0 | 2.8 | 1.4 | 1.0–2.0 | |||||||
| DPB1* | |||||||||||
| 0101 | 11.4 | 8.0 | 2E-4 | 0.7 | 0.6–0.8 | 0103-0101 | 2.8 | 0.7 | 2E-10 | 0.2 | 0.1–0.4 |
| 0201-0101 | 7.5 | 6.3 | 0.8 | 0.7–1.0 | |||||||
| 0201 | 13.0 | 15.2 | 1.2 | 1.0–1.4 | 0103-0201 | 12.1 | 14.7 | 1.3 | 1.1–1.5 | ||
| 0202 | 1.4 | 2.8 | 2E-3 | 2.0 | 1.4–3.0 | 0103-0202 | 1.4 | 2.8 | 2E-3 | 2.1 | 1.4–3.0 |
| 0301 | 10.1 | 15.6 | 4E-8 | 1.6 | 1.4–2.0 | 0103-0301 | 10.0 | 15.3 | 5E-8 | 1.6 | 1.4–1.9 |
| 0401 | 40.8 | 39.9 | 1.0 | 0103-0401 | 38.9 | 38.7 | 1.0 | 0.9–1.1 | |||
| 0201-0401 | 1.2 | 0.7 | 0.6 | 0.3–1.0 | |||||||
| 0402 | 10.9 | 5.3 | 2E-14 | 0.5 | 0.4–0.6 | 0103-0402 | 10.7 | 5.1 | 7E-15 | 0.5 | 0.4–0.5 |
| 0501 | 1.1 | 1.7 | 1.6 | 1.0–2.5 | |||||||
| 0601 | 1.5 | 2.2 | 1.5 | 1.0–2.3 | 0103-0601 | 1.4 | 2.2 | 1.6 | 1.1–2.3 | ||
| 1001 | 1.7 | 1.0 | 0.6 | 0.4–0.9 | 0201-1001 | 1.7 | 0.9 | 0.05 | 0.5 | 0.3–0.8 | |
| 1101 | 1.6 | 0.9 | 0.5 | 0.3–0.9 | 0201-1101 | 1.6 | 0.8 | 0.03 | 0.5 | 0.3–0.8 | |
| 1501 | 0.5 | 1.5 | 2E-3 | 3.0 | 1.6–5.4 | 0104-1501 | 0.5 | 1.0 | 2 | 1.1–3.7 |
Only alleles or haplotypes with a frequency >5% in an individual category or >1% where the nominal P value was <0.05 were compared. The nominal P value was adjusted (Padj) for multiple alleles or haplotypes by applying the Bonferroni correction of multiplying the nominal P value by the number of alleles or haplotypes compared.