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. 2010 Jun 3;59(8):2033–2042. doi: 10.2337/db09-1800

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© 2010 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 6. — Effect of apocynin on pro-fibrotic gene expression. Wild-type mice were rendered diabetic by STZ injection, and apocynin was administrated in the drinking water for 2 months. The mRNA levels of Col I (A), Col III (B), osteopontin (C), α-SMA (D), TGF-β1 (E), and TNF-α (F) were quantified in heart tissues by real-time RT-PCR. Data are means ± SD, n = 6–8. *P < 0.05 vs. nondiabetes in vehicle; #P < 0.05 vs. diabetes in vehicle. O.D., optical density.