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. 2010 Jun 3;59(8):1991–2000. doi: 10.2337/db09-1537

FIG. 4.

FIG. 4.

TRB1 haploinsufficiency protects against high-fat diet–induced obesity. A and B: Body weight (A) and total body fat (B) content as determined by magnetic resonance technology in wild-type (wt) or TRB1 heterozygous knockout mice (TRB1+/−) placed on a low-fat (LFD; 10% calories from fat) or high-fat (HFD; 60% calories from fat) diet for the indicated time points. C and D: Glucose (C) and insulin (D) tolerance tests in the same mice as in A and B. E: Quantitative PCR analysis of IL-1β, TNF-α, and PAI-1 mRNA levels in WAT of the same mice as in A and B after 13 weeks on a low- or high-fat diet (means ± SE, n = 3–4). *High-fat diet wild type versus low-fat diet wild type; $TRB1+/− high-fat diet vs. wild type high fat diet; *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001.