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. 2010 May 18;59(8):1906–1914. doi: 10.2337/db09-1365

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© 2010 by the American Diabetes Association.

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FIG. 2. — Decreased gluconeogenesis and hepatic glucose production in Ptpn2+/− mice. A: Expression of the 45-kDa (TC45) and 48-kDa (TC48) variants of TCPTP in white adipose tissue (epididymal; WAT), liver, muscle (gastrocnemius), and spleen, as well as immortalised Ptpn2−/− and +/+ mouse embryo fibroblasts (MEFs). B and C: Eight- to 10-week-old Ptpn2+/− and +/+ littermate male mice were fed a high-fat diet for 15 weeks and (B) pyruvate tolerance tests, or (C) hyperinsulinaemic-euglycemic clamps performed. Glucose infusion and disappearance rates were determined and whole-body glucose production determined by subtracting the glucose infusion rate from the glucose appearance rate. Results shown are means ± SE; *P < 0.05 by a two-tailed Student t test.