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. 2010 May 18;59(8):1906–1914. doi: 10.2337/db09-1365

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© 2010 by the American Diabetes Association.

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FIG. 5. — Increased insulin and IL-6 signaling in Ptpn2+/− hepatocytes. (A and B) Ptpn2+/− versus +/+ hepatocytes were serum starved for 4 h and stimulated with 10 nmol/l insulin or 1 ng/ml IL-6, as indicated, and processed for immunoblot analysis. C: Control HeLa cells or those expressing TCPTP-specific shRNAs were serum-starved for 4 h, stimulated with 10 ng/ml IL-6 for 10 min, medium replenished, and cells collected at the indicated times for immunoblot analysis. Results shown are representative of three independent experiments.