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. 2010 May 18;59(8):1906–1914. doi: 10.2337/db09-1365

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© 2010 by the American Diabetes Association.

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FIG. 6. — Increased insulin- and IL-6–induced Pck1 and G6pc suppression in Ptpn2+/− hepatocytes. Ptpn2+/− versus +/+ hepatocytes were serum starved for 4 h ± 2 μmol/l CMP6 (Calbiochem) for the last hour and stimulated with (A) 10 nmol/l insulin, or (B and C) 1 ng/ml IL-6 for the indicated times and processed for quantitative (ΔΔCt) RT-PCR to measure the expression of Pck1 and G6pc. C: Lysates from control and IL-6 (1 h) ± CMP6-treated hepatocytes were also processed for immunoblot analysis. Results shown are means ± SE of three independent experiments performed in quadruplicate.