TABLE 1.
Association of candidate SNPs with diabetic nephropathy in 4 independent Japanese populations
| SNP (risk allele)* position† | Study 1 |
Study 2 |
Study 3 |
Study 4 |
||||
|---|---|---|---|---|---|---|---|---|
| P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | |
| rs39059 (A) | 0.11 | 1.14 (0.97–1.35) | 0.83 | 0.98 (0.84–1.15) | 0.03 | 1.93 (1.08–3.42) | 0.39 | 1.12 (0.87–1.43) |
| Ch7, 29255470 | 0.15‡ | 1.16 (0.95–1.43) | 0.88‡ | 1.01 (0.86–1.20) | 0.26‡ | 1.54 (0.72–3.28) | 0.83‡ | 0.97 (0.72–1.30) |
| rs39075 (G) | 0.23 | 1.11 (0.94–1.30) | 0.94 | 0.99 (0.85–1.16) | 0.07 | 1.72 (0.96–3.09) | 0.44 | 1.10 (0.86–1.41) |
| Ch7, 29276692 | 0.14‡ | 1.17 (0.95–1.43) | 0.77‡ | 1.03 (0.87–1.21) | 0.36‡ | 1.44 (0.66–3.14) | 0.71‡ | 0.95 (0.70–1.27) |
| rs1888747 (G) | 0.35 | 1.10 (0.90–1.36) | 0.86 | 0.98 (0.81–1.19) | 0.03 | 0.50 (0.27–0.93) | 0.12 | 0.79 (0.58–1.06) |
| Ch9, 86155551 | 0.10‡ | 1.24 (0.96–1.61) | 0.84‡ | 1.02 (0.83–1.26) | 0.004‡ | 0.28 (0.12–0.67) | 0.43‡ | 0.87 (0.61–1.23) |
| rs10868025 (A) | 0.53 | 1.06 (0.88–1.28) | 0.41 | 0.93 (0.78–1.11) | 0.29 | 0.73 (0.40–1.31) | 0.26 | 0.86 (0.65–1.12) |
| Ch9, 86164176 | 0.31‡ | 1.12 (0.89–1.42) | 0.54‡ | 0.94 (0.78–1.14) | 0.07‡ | 0.49 (0.22–1.06) | 0.33‡ | 0.85 (0.62–1.18) |
| rs739401 (C) | 0.45 | 1.07 (0.90–1.28) | 0.85 | 0.98 (0.83–1.16) | 0.13 | 0.63 (0.34–1.15) | 0.69 | 0.95 (0.73–1.23) |
| Ch11, 3036324 | 0.30‡ | 1.12 (0.90–1.39) | 0.91‡ | 1.01 (0.85–1.21) | 0.25‡ | 0.62 (0.27–1.42) | 0.82‡ | 1.04 (0.76–1.42) |
| rs451041 (A) | 0.11 | 1.17 (0.97–1.41) | 0.60 | 1.05 (0.88–1.25) | 0.25 | 0.69 (0.36–1.31) | 0.86 | 0.98 (0.74–1.29) |
| Ch11, 3060725 | 0.049‡ | 1.26 (1.00–1.59) | 0.42‡ | 1.08 (0.90–1.30) | 0.26‡ | 0.60 (0.25–1.46) | 0.91‡ | 1.02 (0.73–1.43) |
| rs1041466 (G) | 0.11 | 1.26 (0.95–1.66) | 0.51 | 1.11 (0.82–1.48) | 0.16 | 0.35 (0.08–1.50) | 0.92 | 0.98 (0.67–1.43) |
| Ch13, 110244322 | 0.18‡ | 1.27 (0.90–1.80) | 0.18‡ | 1.27 (0.90–1.80) | 0.12‡ | 0.15 (0.01–1.59) | 0.44‡ | 1.20 (0.76–1.88) |
| rs1411766 (A) | 0.045 | 1.33 (1.01–1.75) | 0.08 | 1.24 (0.98–1.56) | 0.75 | 0.86 (0.32–2.29) | 0.21 | 1.26 (0.88–1.82) |
| Ch13, 110252160 | 0.009‡ | 1.58 (1.12–2.22) | 0.08‡ | 1.26 (0.98–1.62) | 0.33‡ | 0.50 (0.12–2.01) | 0.046‡ | 1.55 (1.01–2.39) |
| rs6492208 (T) | 0.61 | 1.05 (0.89–1.23) | 0.71 | 0.97 (0.83–1.14) | 0.68 | 1.13 (0.64–1.98) | 0.36 | 1.12 (0.88–1.43) |
| Ch13, 110257726 | 0.74‡ | 0.97 (0.79–1.19) | 0.48‡ | 0.94 (0.79–1.11) | 0.82‡ | 0.91 (0.40–2.05) | 0.13‡ | 1.25 (0.93–1.67) |
| rs7989848 (A) | 0.75 | 1.03 (0.87–1.22) | 0.999 | 1.00 (0.85–1.17) | 0.79 | 1.08 (0.60–1.95) | 0.11 | 1.23 (0.95–1.58) |
| Ch13, 110283468 | 0.98‡ | 0.998 (0.81–1.23) | 0.60‡ | 0.96 (0.80–1.14) | 0.55‡ | 0.78 (0.34–1.78) | 0.03‡ | 1.42 (1.05–1.92) |
| rs9521445 (A) | 0.76 | 1.03 (0.87–1.22) | 0.75 | 1.03 (0.88–1.20) | 0.97 | 0.99 (0.55–1.78) | 0.09 | 1.25 (0.97–1.62) |
| Ch13, 110285534 | 0.84‡ | 0.98 (0.79–1.21) | 0.82‡ | 0.98 (0.82–1.16) | 0.45‡ | 0.72 (0.30–1.69) | 0.02‡ | 1.45 (1.07–1.97) |
*Risk allele reported in the GoKinD populations.
†Data from the National Center for Biotechnology Information database (Entrez SNP, Genome Reference Consortium Human Build 37.1; http://www.ncbi.nlm.nih.gov/sites/entrez?db=snp).
‡Adjusted for age, sex, BMI, and duration of type 2 diabetes in studies 1, 3, and 4, and for age, sex, and BMI in study 2.