TABLE 2.
Results of a meta-analysis of four independent Japanese studies on the association of 11 SNPs with diabetic nephropathy
| SNP (risk allele)* | Proteinuria (Studies 1, 2, and 3) |
Proteinuria + ESRD (all studies) |
||||
|---|---|---|---|---|---|---|
| P | OR (95% CI) | P for heterogeneity | P | OR (95% CI) | P for heterogeneity | |
| rs39059 (A) | 0.19 | 1.08 (0.96–1.20) | 0.06 | 0.12 | 1.08 (0.98–1.20) | 0.12 |
| rs39075 (G) | 0.28 | 1.06 (0.95–1.19) | 0.18 | 0.19 | 1.07 (0.97–1.18) | 0.31 |
| rs1888747 (G) | 0.99 | 1.00 (0.87–1.15) | 0.06 | 0.51 | 0.96 (0.85–1.09) | 0.05 |
| rs10868025 (A) | 0.68 | 0.97 (0.86–1.10) | 0.37 | 0.40 | 0.95 (0.85–1.07) | 0.44 |
| rs739401 (C) | 0.96 | 1.00 (0.89–1.13) | 0.24 | 0.91 | 0.99 (0.89–1.11) | 0.38 |
| rs451041 (A) | 0.22 | 1.08 (0.95–1.23) | 0.26 | 0.30 | 1.06 (0.95–1.19) | 0.37 |
| rs1041466 (G) | 0.16 | 1.15 (0.95–1.41) | 0.21 | 0.23 | 1.11 (0.93–1.33) | 0.29 |
| rs1411766 (A) | 0.01 | 1.26 (1.06–1.50) | 0.69 | 0.004 | 1.26 (1.07–1.47) | 0.86 |
| rs6492208 (T) | 0.90 | 1.01 (0.90–1.13) | 0.78 | 0.62 | 1.03 (0.93–1.14) | 0.78 |
| rs7989848 (A) | 0.82 | 1.01 (0.90–1.14) | 0.96 | 0.39 | 1.05 (0.94–1.16) | 0.59 |
| rs9521445 (A) | 0.69 | 1.02 (0.91–1.15) | 0.99 | 0.29 | 1.06 (0.95–1.17) | 0.58 |
Meta-analysis was performed using the Mantel-Haenszel test.
*Risk allele reported in the GoKinD populations. ESRD, end-stage renal disease.