TABLE 3.
Results of a meta-analysis of 4 independent Japanese studies and U.S.-GoKinD study on the association of 11 SNPs with diabetic nephropathy
| SNP (risk allele)* | Risk allele frequencies (case/control) |
Meta-analysis |
||||||
|---|---|---|---|---|---|---|---|---|
| Study 1 | Study 2 | Study 3 | Study 4 | GoKind* | P for heterogeneity | Original P† | Combined P | |
| rs39059 (A) | 0.55/0.52 | 0.51/0.52 | 0.68/0.52 | 0.56/0.53 | 0.68/0.60 | 0.0099 | 6.7 × 10−6 | 0.038‡ |
| rs39075 (G) | 0.55/0.52 | 0.53/0.53 | 0.68/0.56 | 0.57/0.55 | 0.65/0.57 | 0.010 | 1.5 × 10−6 | 0.051‡ |
| rs1888747 (G) | 0.81/0.80 | 0.80/0.80 | 0.70/0.82 | 0.77/0.81 | 0.74/0.66 | 5.8 × 10−5 | 1.3 × 10−6 | 0.912‡ |
| rs10868025 (A) | 0.74/0.73 | 0.72/0.73 | 0.67/0.73 | 0.70/0.73 | 0.66/0.58 | 0.00027 | 1.1 × 10−6 | 0.851‡ |
| rs739401 (C) | 0.33/0.32 | 0.33/0.33 | 0.28/0.39 | 0.32/0.33 | 0.55/0.48 | 0.0053 | 1.7 × 10−5 | 0.606‡ |
| rs451041 (A) | 0.27/0.24 | 0.27/0.26 | 0.23/0.31 | 0.26/0.27 | 0.55/0.47 | 0.033 | 8.1 × 10−6 | 0.166‡ |
| rs1041466 (G) | 0.11/0.09 | 0.11/0.10 | 0.03/0.09 | 0.12/0.12 | 0.49/0.41 | 0.13 | 2.6 × 10−6 | 8.3 × 10−6 |
| rs1411766 (A) | 0.12/0.09 | 0.13/0.11 | 0.09/0.10 | 0.15/0.12 | 0.39/0.32 | 0.77 | 1.9 × 10−6 | 4.9 × 10−8 |
| rs6492208 (T) | 0.43/0.42 | 0.43/0.44 | 0.41/0.39 | 0.45/0.42 | 0.63/0.56 | 0.015 | 5.4 × 10−6 | 0.152‡ |
| rs7989848 (A) | 0.37/0.37 | 0.38/0.38 | 0.33/0.32 | 0.40/0.35 | 0.57/0.49 | 0.032 | 1.2 × 10−5 | 0.084‡ |
| rs9521445 (A) | 0.36/0.36 | 0.38/0.37 | 0.31/0.31 | 0.39/0.34 | 0.55/0.47 | 0.026 | 3.7 × 10−6 | 0.072‡ |
Meta-analysis was performed using the Mantel-Haenszel test with a fixed-effects model, or the
‡DerSimonian-Laird method with a random effect model.
*Risk allele reported in the GoKinD populations.
†P values for allelic association model are calculated from the data in original report by Pezzolesi et al. (14).