Table 3.
Patterns of pfcrt and pfmdr1 point mutations from the 45 isolates tested for CQ in vitro susceptibility*
| pfcrt codons | pfmdr1 codons | pfcrt/pfmdr1 codons | ||||||
|---|---|---|---|---|---|---|---|---|
| In vitro test result | Wt K76 | Mut T76 | Wt N86 | Mut Y86 | Wt/wt | Wt/mut | Mut/wt | Mut/mut |
| K76/N86 | K76/Y86 | T76/N86 | T76/Y86 | |||||
| Sensitive (N = 25) | 12 (48%) | 13 (52%) | 14 (56%) | 11 (44%) | 11 (44%) | 1 (4%) | 3 (12%) | 10 (40%) |
| Low resistant (N = 17) | 3 (17%) | 14 (82.4%) | 3 (17.6%) | 14 (82.4%) | 1 (5.9%) | 2 (11.8%) | 2 (11.8%) | 12 (70.6%) |
| Marked resistant (N = 3) | 2 (66.7%) | 1 (33.3%) | 3 (100%) | 0 | 2 (66.7%) | 0 | 1 (33.3%) | 0 |
*
N = no. isolates; wt = wild-type codon; mut = mutant codon.