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. 2010 Apr 19;588(Pt 12):2173–2191. doi: 10.1113/jphysiol.2010.190462

Figure 2. The effect of PI-3K inhibitors on I/R-induced injury and IP in rat ventricular myocardium.

Figure 2

LY 294002 (10 μm) and wortmannin (0.1 μm) were used to investigate the role of PI-3K in ischaemia/reoxygenation (I/R)-induced injury and ischaemic preconditioning (IP) following the protocols shown in Aa and Ab. In all cases tissue samples were analysed for CK release during the 120 min reoxygenation (Ba and Bb), and for necrosis (Ca and Cb) and apoptosis (Da and Db) at the end of 120 min of reoxygenation. Data represent the mean ±s.e.m. from 6 independent experiments. *P < 0.05 vs. I/R alone group.