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. 2010 Apr 19;588(Pt 12):2173–2191. doi: 10.1113/jphysiol.2010.190462

Figure 3. The temporal effects of PKB inhibitor XI administration during I/R.

Figure 3

As shown in A, PKB inhibitor XI (1 μm) was administered at 5 different time points during the ischaemia/reoxygenation (I/R) protocol using rat left ventricular myocardial slices: 20 min before ischaemia; during ischaemia; during reoxygenation; during ischaemia and reoxygenation; and before ischaemia and throughout ischaemia and reoxygenation. In all cases tissue samples were analysed for CK release during the 120 min reoxygenation (B), and for necrosis (C) and apoptosis (D) at the end of 120 min reoxygenation. Data represent the mean ±s.e.m. from 6 independent experiments. *P < 0.05 vs. I/R alone group; †P < 0.05 vs. before I and throughout groups.